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Restore Physician Partners....
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What The NIH Says About Ketamine

"Recent data suggest that ketamine, given intravenously, might be the most important breakthrough in antidepressant treatment in decades"....


Thomas Insel MD, Director, National Institute of Mental Health

Restore...A New Therapeutic Option For Depression And Pain

The Restore Ketamine Infusion offers the most advanced formulation of ketamine therapy available today. Restore gives physicians and patients with an exciting new therapeutic option for severe depression, chronic pain and post-traumatic stress disorder.


The Ketamine Institute has over 15 years of clinical and research experience in the application of ketamine based infusions for chronic pain an mood disorder in major academic institutions.    As a former Assistant Professor of Anesthesiology and Pain Medicine at the Yale University School of Medicine, I had the opportunity and privilege of working with members of the Department of Anesthesiology and Psychiatry in the clinical use and application of ketamine to treat chronic pain syndromes as well as related mood and addiction disorders. This included collaborating with members of John Krystal and Dave Charney’s group at Yale who published the first randomized, placebo controlled trial on the use of ketamine in patients with treatment resistant major depression   

(Berman RM, Krystal JH, et. al. Antidepressant effects of ketamine in depressed patients, Biol Psychiatry 2000; 47(4): 351-354).


Additional work conducted while at Yale, Mount Sinai Medical Center and SUNY Stony Brook School of Medicine has shown that intravenous ketamine is a rapidly acting analgesic and anti-depressant that can achieve symptom reduction, improved mood and function in over 75% of patients who have treatment resistant depression or chronic pain within minutes to hours of administration.


We would be happy to work with you in the treatment of any of your patients who are not responding, as well as hoped, to conventional first and second line agents or therapies.


Appropriate Patients For Treatment with....
The Restore Ketamine Infusion 


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Restore Patient Selection

An appropriate patient for the Restore Ketamine Infusion would generally be those suffering from a major depressive disorder or chronic intractable pain syndrome that has not responded to two or more fist and second line medications.


Mood Disorders - Depression / Anxiety / PTSD / OCD

Appropriate patients with a major depressive disorder without psychotic features would be those who have been treated with at least 2 different types of medication from two different drugs classes and has not obtained any significant benefit from therapy. In addition, patients who have failed to improve with bilateral ECT and rTMS therapy are also candidates for infusion therapy.


Patients with treatment resistant Anxiety Disorders, Obsessive Compulsive Disorders (OCD) and Post-Traumatic Stress Disorders (PTSD) may also benefit from Restore therapy.


Chronic Pain - CRPS/RSD / Fibromyalgia / PHN

Chronic pain patients who may benefit from Restore therapy include those with neuropathic pain syndromes that are not well controlled with opioids, injections, nerve blocks, neuromodulation therapy or or other prescription pain medication. Appropriate pain syndromes include complex regional pain syndrome (CRPS/RSD), trigeminal neuralgia, phantom limb pain, post-herpetic neuralgia, and migraine headache, etc. In addition, patients with chronic back and neck pain no longer responsive to any form of treatment or with other debilitating musculoskeletal and joint pain such as Fibromyalgia are candidates for infusion therapy.


Medical Considerations Prior To Treatment with....
The Restore Ketamine Infusion 


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Contraindications To Restore Therapy

Of course, there are some individuals with specific medical conditions who would not be appropriate candidates for this type of therapy.  In addition, several medications are known to compete at the NMDA/AMPA and/or the D2-3 receptor and therefore limited the clinical effectiveness of ketamine.


Pre-Exisiting Medical Conditions

• Known hypersensitivity (Allergy) to ketamine,
• A recent myocardial infarction: < 6 months ago,
• Unstable Angina / Accelerated Hypertension,
• Uncompensated CHF/pulmonary hypertension,
• Known / suspected Cerebral Aneurysm or AVM,
• A recent hemorrhagic stroke: < 1 year ago


Please contact us if you have any questions about potential medical contraindications to Restore Therapy. 

Medication Interactions

• Risperdal (risperidone),
• Zyprexa (olanzapine),
• Lamictal (lamotrigine).


Any patient currently on these medications would require a downward titration leading to a temporary discontinuation for approximately 2 weeks before the infusion series and during the course of ketamine therapy. The medication may be resumed following completion of the infusion series if clinically indicated.




An Exciting New And Effective Treatment Option....
The Restore Ketamine Infusion 


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The Ketamine Institute

The Ketamine Institute is leading the way in the field of ketamine infusion therapy with our new Restore Ketamine Infusion. We’re on a mission to accelerate the health care revolution. We have pioneered  Restore infusion therapy to bring the latest breakthrough discoveries about ketamine out of the research lab and into our infusion centers.


The Ketamine Institute offers Physician Ketamine Infusion Training Programs for those physicians who wish to learn more about this effective therapy or become partner Restore Infusion Centers.  Contact the Ketamine Institute for more information.


How To Refer A Patient For Treatment with....
The Restore Ketamine Infusion 


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Refer A Patient For Consultation
Call - 800.850.6979

Please feel free to contact us to determine if Restore is appropriate therapy for your patients. Call us today or submit this form request for a consultation.

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